An abnormal test result does NOT mean that your baby definitely has a birth defect. This means it does not diagnose birth defects. Philadelphia, PA: Elsevier; 2021:chap 10. Normal value ranges may vary slightly among different laboratories. This test is a screening test, so it does not diagnose problems. This test is most often done between the 15th and 22nd weeks of the pregnancy. Philadelphia, PA: Elsevier; 2021:chap 10. PMID: 26938573 pubmed.ncbi.nlm.nih.gov/26938573/. You may feel slight pain or a sting when the needle is inserted. A blood test can be performed between the 15th and 22nd weeks of the pregnancy to determine whether the baby is at risk for certain birth defects. 2016;127(5):e108-e122. For information on how this is done, see: Venipuncture. This test is most often done between the 15th and 22nd weeks of the pregnancy. Normal value ranges may vary slightly among different laboratories. (measured in weeks from the day of your last period to the current date), Tests to detect or rule out certain birth defects (such as Down syndrome), Ultrasound to check the baby’s brain, spinal cord, kidneys, and heart, Absence of part of the brain and skull (anencephaly), Defect in the baby's intestines or other nearby organs (such as duodenal atresia This test is a screening test, so it does not diagnose problems. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. More tests are needed to confirm an abnormal result. However, some people choose not to have any more tests done, for personal or religious reasons. 9th ed. A blood test can be performed between the 15th and 22nd weeks of the pregnancy to determine whether the baby is at risk for certain birth defects. Normal levels of AFP, hCG, uE3, and inhibin A. Talk to your health care provider about the meaning of your specific test results. Normal Results Normal levels of AFP, hCG, uE3, and inhibin A. Talk to your health care provider about the meaning of your specific test results. The quadruple screen test is a blood test done during pregnancy to determine whether the baby is at risk for certain birth defects. Textbook of Family Medicine. More tests are needed to confirm an abnormal result. If the test is abnormal, you may want to talk to a genetic counselor. 2009;79:117-123. Low levels of AFP and estriol and high levels of hCG and inhibin A may be due to a problem such as: Veins and arteries vary in size from one patient to another and from one side of the body to the other. Possible next steps include: During pregnancy, increased levels of AFP may be due to a problem with the developing baby, including: High AFP can also mean that you’re carrying more than one baby. Tests to detect or rule out certain birth defects (such as Down syndrome). This test is usually performed between the 15th and 22nd weeks of the pregnancy, but it is most accurate between the 16th and 18th weeks. 8th ed. 8th ed. Philadelphia, PA: Elsevier; 2019:chap 32. Often, the results can be abnormal if your baby is older or younger than your provider had thought. Information developed by A.D.A.M., Inc. regarding tests and test results may not directly correspond with information provided by UCSF Medical Center. The quadruple screen test is a blood test done during pregnancy to determine whether the baby is at risk for certain birth defects. Driscoll DA, Morgan MA, Schulkin J. Williams DE, Pridjian G. Obstetrics. Need a doctor? You may also feel some throbbing at the site after the blood is drawn. Tests to detect or rule out certain birth defects (such as Down syndrome). In: Landon MB, Galan HL, Jauniaux ERM, et al, eds. Instead, it is used to determine whether your baby has a higher risk of these defects. The quad screen (sometimes referred to as the quadruple screen, AFP4, or multiple marker) is a blood test that can tell you whether your baby is at an increased risk for certain conditions. 9th ed. 7th ed. Certain women are at greater risk of having a baby with these defects, including: Normal levels of AFP, hCG, uE3, and inhibin A. New York Eye and Ear Infirmary of Mount Sinai, The Blavatnik Family – Chelsea Medical Center, Heart - Cardiology and Cardiovascular Surgery, Mount Sinai – Sema4 Health Discovery Initiative Patient Opt Out Registry, Alpha-fetoprotein (AFP), a protein produced by the baby, Human chorionic gonadotropin (hCG), a hormone produced in the placenta, Unconjugated estriol (uE3), a form of the hormone estrogen produced in the fetus and the placenta, Inhibin A, a hormone released by the placenta, Women who are over 35 years old during pregnancy, Women with a family history of birth defects. ACOG Practice Bulletin No. However, some people choose not to have any more tests done, for personal or religious reasons. ACOG Committee on Practice Bulletins. Normal value ranges may vary slightly among different laboratories. Screening for Downsyndrome: changing practice of obstetricians. Obtaining a blood sample from some people may be more difficult than from others. Any duplication or distribution of the information contained herein is strictly prohibited. Creasy and Resnik's Maternal-Fetal Medicine: Principles and Practice. ), Death of the baby inside the womb (usually results in a miscarriage), Hematoma (blood accumulating under the skin), Infection (a slight risk any time the skin is broken). Philadelphia, PA: Elsevier; 2016:chap 20. Talk to your health care provider about the meaning of your specific test results. 2016;127(5):e108-e122. To determine the chance of your baby having a birth defect, the test also factors in: No special steps are needed to prepare for the test. The test identifi es about 6 out of 10 cases of Edwards’ syndrome. PMID: 26938573 pubmed.ncbi.nlm.nih.gov/26938573/. It is most accurate between the 16th and 18th weeks. Am Fam Physician. This test is a screening test. Call 911 for all medical emergencies. Philadelphia, PA: Elsevier; 2019:chap 32. Creasy and Resnik's Maternal-Fetal Medicine: Principles and Practice. Genetic screening and prenatal genetic diagnosis. Obstet Gynecol. Blood is drawn from a vein and the sample is sent to a laboratory for testing. Gabbe's Obstetrics: Normal and Problem Pregnancies. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. Ultrasound to check the baby's brain, spinal cord, kidneys, and heart. The test measures levels of four pregnancy hormones: If the test does not measure levels of inhibin A, it is called the triple screen test. Possible next steps include: During pregnancy, increased levels of AFP may be due to a problem with the developing baby, including: High AFP can also mean that you are carrying more than 1 baby.

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