Chemsrc provides Cinnamic acid(CAS#:621-82-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Freely sol in alcohol, ether. Products are for research use only. mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. Calcitriol (RO215535, Topitriol) is a nonselective vitamin D receptor activator/agonist(VDRA), exhibiting a 10-fold higher vitamin D receptor (VDR) binding affinity(IC50=0.4 nM) than the selective VDRA paricalcitol. expression of Bcl-2 (a marker of cell proliferation) is reduced, and apoptosis is induced by Cinnamic acid[2]. Thus, cinnamic acid exhibits a low toxicity, trans-Cinnamic acid, Phenylacrylic acid, Cinnamylic acid, 3-Phenylacrylic acid|(E)-Cinnamic acid, Benzenepropenoic acid, Isocinnamic acid, Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment). 1995 Jul 28;62(3):345-50. 1082617 ; United States Pharmacopeia (USP) … Treatment with Cinnamic acid (CINN) of various tumor cells of epithelial and neuroectodermal origin result in dose-dependent growth inhibition following a 3-day exposure. Cyclosporin A (Cyclosporine A) is an immunosuppressive agent, binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay, widely used in organ transplantation to prevent rejection. 1995 Jul 28;62(3):345-50. Soluble in 3 vols of 70% alc. Note:1.Please make sure the liquid is clear before adding the next solvent. Method for preparing in vivo formulation:Take μL Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). Telaglenastat (CB-839) is a potent, selective, and orally bioavailable glutaminase inhibitor with IC50 of 24 nM for recombinant human GAC. 1.012. Free Overnight Delivery on orders over $ 500 2013, 32:31. Cells are grown for 3 days at 37°C in the presence or absence of the drug, then detached with trypsin/EDTA and counted in a Coulter counter. check more Cinnamic acid price, Home | Incompatible with strong oxidizing agents. The change in the capacity of Cinnamic acid -treated melanoma 1011, A375(M) and SKMEL28 cells to degrade and cross tissue barriers is assessed by an in vitro invasion assay using modified Boyden chambers with matrigel-coated filters. BAPTA-AM is a selective, membrane-permeable calcium chelator. Catalog No.S3677 * When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online). Combustible. drug pre-dissolved in μL DMSO (Master liquid concentration Calculate the dilution required to prepare a stock solution. Cinnamic acid shows genotoxic potential at both tested concentrations, inducing the formation of micronucleated cells[1]. Selling Leads | In addition to inhibiting tumor-cell proliferation, Cinnamic acid causes morphological changes consistent with melanocyte differentiation. CAS Number: 538-65-8. The alkali salts are sol in water. The inhibitory concentrations causing a 50% reduction in tumor-cell proliferation (IC50) are between 1.2 to 4.5 mM. Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol. Int J Cancer. About Us | Cinnamic acid (tCA) upregulates the expression of acetyl‑H3 and acetyl‑H4 proteins in a dose-dependent manner in treated cells and in the tumor tissue of treated mice. Growth rates are determined by cell counting. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments. Miscible with alcohol, ether. Very sparingly sol in water (<0.5%). GKT137831 partly inhibits ferroptosis. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving. One gram dissolves in about 2000 ml water at 25° (more sol in hot water), in 6 ml alc, 5 ml methanol, 12 ml chloroform. Method for preparing in vivo formulation:Take [2] Zhu B, et al. Insol in water. Cinnamic acid: a natural product with potential use in cancer intervention. Int J Cancer. SDS; 78714 ; reference material; Supelco pricing. Shanghai Jizhi Biochemical Technology Co., Ltd. Cinnamic acid has potential use in cancer intervention, with IC50s of 1-4.5 mM in glioblastoma, melanoma, prostate and lung carcinoma cells. 1.5766. An appropriate control with DMEM, 20% PBSA and 1% ethanol was … Cinnamic acid reduces cell proliferation of glioblastoma, melanoma, prostate and lung carcinoma cells by 50% at concentrations between 1.0 and 4.5 mM. Purity (HPLC) ≥95% Melting point : 132-136°C Molecular Weight : 148.1586 g/mol Other Names : benzal acetate, 3-phenyl-2-propenoic acid,CinnamonAcid, Cinnamyl Acid, Nsc9189 CAS No : 621-82-9 It is also showed that 20 mM Cinnamic acid is needed to cause an IC50 in FS4 cells, i.e. SDS; Butyl cinnamate. J Exp Clin Cancer Res. pK (25°) 4.46. uv max (alc): 273 nm. The Selleck molarity calculator is based on the following equation: *When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages). 147°. The antiproliferative activity of the drug is associated with caspase 9 activation, but not p53 … English name: alpha-Methylcinnamic acid Other names: 2-Propenoic acid, 2-methyl-3-phenyl-; Cinnamic acid, α-methyl-; 2-Methyl-3-phenyl-2-propenoic acid Molecular Formula: C10H10O2 CAS No. Buying Leads | Mol Med Rep. 2016, 13(5):4159-66. Freely sol in benzene, ether, acetone, glacial acetic acid, carbon disulfide, oils. (1 u is equal to 1/12 the mass of one atom of carbon-12) Biologically Active Compounds | Practically insol in water. Tags: buy Cinnamic acid | Cinnamic acid supplier | purchase Cinnamic acid | Cinnamic acid cost | Cinnamic acid manufacturer | order Cinnamic acid | Cinnamic acid distributor, In vivo Formulation Calculator (Clear solution), Antineoplastic and Immunosuppressive Antibiotics, Selection Antibiotics for Transfected Cell, FDA-approved & Passed Phase I Drug Library, Human Endogenous Metabolite Compound Library, Anti-Cardiovascular Disease Compound Library, Cytoskeletal Signaling Pathway Compound Library, Endoplasmic Reticulum Stress Compound Library, Protein-protein Interaction Inhibitor Library, Small Molecule Immuno-Oncology Compound Library. Cinnamic acid: a natural product with potential use in cancer intervention. After 3 days of continuous treatment with Cinnamic acid, a dose-dependent loss of invasive capacity in 3 tested tumor lines is observed. C10H16N2O2 c10h16n2o2. Enter the chemical formula of a compound to calculate its molar mass and elemental composition: Tip: Chemical formula is case sensitive. Puromycin 2HCl is an aminonucleoside antibiotic, which acts as a protein synthesis inhibitor. Ribavirin (NSC-163039, ICN-1229, RTCA, Tribavirin), a synthetic guanosine analogue, possesses a broad spectrum of activity against DNA and RNA viruses. LB-100 is a water soluble protein phosphatase 2A (PP2A) inhibitor with IC50s of 0.85 μM and 3.87 μM in BxPc-3 and Panc-1 cells. Molecular Weight: 238.28. CB-839(Telaglenastat) inudces autophagy and has antitumor activity. DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Treatment with 5 mM Cinnamic acid results in 75-95% loss of invasiveness[1].

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